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Hepatoprotective Activity of Ethanolic and ethyl acetate Extracts of Sterculia Setigera Against Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats

Tarig Hussein Abdelrahman


The ethanolic and ethyl acetate extracts of Sterculia Setigera stem bark that belonging to the family of Sterculiaceae was studied for its hepatoprotective activity against albino rats with liver damage induced by carbon tetrachloride (CCL4). These plants are used in traditional medicine in the treatment of jaundice and other diseases; No systematic studies on their hepatoprotective activity have been reported before.

The hepatotoxcity was produced by administration of carbon tetrachloride (CCL4) at a dose of 0.2 ml/kg for 10 days. Treatment was carried out by oral administration of the ethanolic and petroleum ether extracts 0f Sterculia Setigera stem bark at a dose 200 and 400 mg/kg body weight.  The hepatoprotective activity was also supported by histopathological studies of liver tissue. The extracts exhibited moderate protective effect by lowering the serum levels of alanine amino transferase (ALT) , Aspartate amino transferase(AST), total protein, Albumin(ALB), Bilirubin concentration and alkaline phosphatase(ALP) to significant extent. In addition the concurrent administration of the extracts with carbon tetrachloride(CCL4) for 10 days masked the liver fatty changes induced by the hepatotoxic compound observed in the control negative rats and compared with hepatoprotective effect of the standard drug Silymarin. 

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- Chaterrjee, T, K “Medicinal Plants with hepatoprotective Properties”. Herbal option Books and Applied AUied (p) L td, Calcutta. 2000, 143.

- Jude, E.O and Paul, A.N. Anti-inflammatory, analgesic and antipyretic activities of ethanolic root extract of croton zambesicus. Phytochemistry. 2007- 51: 171-174

- Karan, M. ,Vasisht,K., Handa,S.S. Anhepato toxic activity of swertia chirata on carhon tetrachlon iduced hepatotoxicity in rats, phytotherapy Research. 1999: 13, 24-30.

- Owoabi, O.J., E.K.I. Omogbai and O. Obasuyi, Antifungal and antibacterial activities of the ethanolic and aqueous extract of Kigella Africana (Bignoniaceae) stem bark. Afr. J. Biotechnology.2007: 6: 1677-1680.

- Reitman, S. and Frankel, S. Amer. J. Clin. Path.1957: 28-56.

Schmidt, E. and Schmidt, F. W. Enzyme, Biol. Clin.1963- 3:1.

- Rubinstein,D. “Epirephnre release and liven glycogen level after canbon tetrachloride administration”. American Journal of physiology.1962: 203, pp.1033-1037.

- Shanma,A., chakraborti K.K, and Handa, S,S. “Anti-hepatotoxic activity of some

Indian herbal formulations as compared to silymarin” Fitoterapia .1991: 62, pp.229-235.

- Shana R. Dalton a,b , Serene M.L. Lee. Carbon tetrachloride-induced liver damage in

asialoglycoprotein receptor-deficient mice. biochemical pharmacology. 2009: 77,1283–1290

- Wagner, H., et al. "The Chemistry of Silymarin (Silybin), the Active Principle of the Fruits of

Silybum marianum." Arzneim-Forsch Drug Res. 1968; 18:688-96.

- Sharma Bhawna and Sharma Upendra Kumar Hepatoprotective activity of some

indigenous plants. International Journal of PharmTech Research. 2009: Vol.1, No.4, pp

- 1334.

- Rajib Ahsan, Km Monirul Islam, A. Musaddik and E. Haque. Hepatoprotective Activity of

Methanol Extract of Some Medicinal Plants Against Carbon Tetrachloride Induced

Hepatotoxicity in Albino Rats- Global Journal of Pharmacology. 2009:3 (3);116-122.

- Isubramoninm, A, and Push pangadan, P. “Development of ply to medicines for liver

diseases”. Indian of pharmacol. 1999) 31, pp.166-175.

- Kamsiah Jaarin , U. Nor-Aini , M.A. Siti-Aishah and Srijit Das. Palm Oil Fat Diet

Consumption and its Effects on Serum Liver Enzymes and Microscopic Changes in

Experimental Rats. Pakistan Journal of Nutrition. 2015:14 (9): 575-580.


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